Tehran University of Medical Sciences Journal of Arthropod-Borne Diseases 2322-1984 15 1 2021 03 31 1434 1434 Yaser Salim Abadi Department of Health Services and Health Promotion, School of Health, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Alireza Sanei-Dehkordi Department of Medical Entomology and Vector Control, Faculty of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Azim Paksa Department of Medical Entomology and Vector Control, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Amin Gorouhi Department of Vector Biology and Control, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran Hassan Vatandoost Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Department of Chemical Pollutants and Pesticides, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran 2021 04 21 Background: Mosquitos due to their role in the transmission of different pathogens to humans are considered as an important group in the phylum Arthropoda. According to the WHO and FAO guideline different groups of insecti­cide applied for controlling pests in both the agricultural and public health sectors. Methods: All the data published about resistant status of the mosquitoes Anopheles, Culex, Aedes and Culiseta spe­cies were searched on PubMed, Elsevier, Web of Science, Magiran and google scholar. The objectives of this study was to review the trend of resistance to insecticides during 2000–2020 in medically important mosquitoes in Iran. The criteria for resistant are followed according to WHO guideline. Results: The Results showed that there are widespread, multiple resistances in the country to different organochlo­rine, organophosphates, carbamate and pyrethroids insecticides in the mosquitoes. Conclusion: The effect of pesticide residues on the environment could be a cause for selection pressure on mosqui­tos and lead to insecticides resistance to them. Insecticides resistance is main challenge of the vector control pro­gram. Also result will provide a guideline for control of the mosquito-borne diseases in the country as well as the world. https://jad.tums.ac.ir/index.php/jad/article/view/1434 https://jad.tums.ac.ir/index.php/jad/article/download/1434/527