Tehran University of Medical Sciences Journal of Arthropod-Borne Diseases 2322-1984 16 3 2023 02 26 1567 1567 EN Mehdi Khoobdel Health Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran Shahyad Azari-Hamidian Research Center of Health and Environment, School of Health, Guilan University of Medical Scienc-es, Rasht, Iran, Department of Medical Parasitology, Mycology and Entomology, School of Medicine, Guilan Univer-sity of Medical Sciences, Rasht, Iran Ahmad Ali Hanafi-Bojd Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Zoonoses Research Center, Tehran University of Medical Sciences, Tehran, Iran Hasan Bakhshi Vector-borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran Amirsajad Jafari Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran Mohammad Moradi Health Research Center, Lifestyle Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran 2022 07 02 2023 02 21 Background: Scabies is referred to the infestation of skin by an ectoparasite, Sarcoptes scabiei. Having considerable financial consequences, this disease is a public health concern in several countries. In this review, we aimed to deter­mine the current status of scabies in different provinces of Iran. Methods: Google Scholar, PubMed, Scopus, Science Direct, Scientific Information Database (SID), Sci-explore, Civil­ica, Magiran, Iranian Research Institute for Information Science and Technology and Elmnet databases were searched to find the related data in the time period within 2000–2022. To have a better insight into the status of prevalence of sca­bies in Iran, a meta-analysis and meta-regression was performed. Results: A total of 943 relevant studies were retrieved from the databases, and 62 eligible studies met all the needed criteria for inclusion in this systematic review. Scabies was investigated and reported in at least 22 and 21 provinces of Iran respectively. Most of the studies were conducted in Tehran, Razavi Khorasan, Hormozgan, Fars and Guilan Prov­inces. Positive samples of scabies belonged to humans, sheep, goats, dogs, rabbits, mice and gazelles. Meta-analysis showed that the overall estimated presence of scabies in Iran during 2000–2022 was 7% (95% CI 4.7–10.3%, P< 0.001). Conclusion: Infestations due to S. scabiei in Iran occur in different geographical locations and different climates. As a neglected tropical disease, the literature about the burden of scabies in Iran is inadequate. The present review highlights the importance of development of comprehensive strategies for the diagnosis and control of scabies, especial­ly the provinces with high infestation rates. https://jad.tums.ac.ir/index.php/jad/article/view/1567 https://jad.tums.ac.ir/index.php/jad/article/download/1567/597