Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever

Tehran University of Medical Sciences Journal of Arthropod-Borne Diseases 2322-1984 11 1 2017 04 18 Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever 19 26 EN Murat Sefikogullari Pediatric Clinic, Private Samandağ Medical Center, Hatay, Turkey Ali Kaya Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey Huseyin Aydin Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey Enver Sancakdar Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey Veysel Kenan Celik Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey Gokhan Bagci Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey 2016 02 17 2016 02 17 Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflammatory process and plasma leakage. The aim of this study was to define HIF-1α and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease. Methods: Thirty cases younger than 17 yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the patient and control groups. Serum levels of HIF-1α and VEGF-A were measured with ELISA. Results: Levels of HIF-1α and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P< 0.05). A significant positive correlation was found between the levels of HIF-1α and VEGF-A in the patient group (P< 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P< 0.001). A positive correlation was found among the levels of AST and CK from biochemical parameters and VEGF and HIF-1α in the patient group (P< 0.05) Conclusion: HIF-1α and VEGF-A might play an important role in CCHF pathogenesis. https://jad.tums.ac.ir/index.php/jad/article/view/387 https://jad.tums.ac.ir/index.php/jad/article/download/387/306