Biological Activities and Composition of Ferulago carduchorum Essential Oil

Fereshteh Golfakhrabadi; Mahnaz Khanavi; Seyed Nasser Ostad; Soodabeh Saeidnia; Hassan Vatandoost; Mohammad Reza Abai; Mitra Hafizi; Fatemeh Yousefbeyk; Yaghoob Razzaghi Rad; Ameneh Baghenegadian; Mohammad Reza Shams-Ardekani

Biological Activities and Composition of Ferulago carduchorum Essential Oil

Fereshteh Golfakhrabadi

Mohammad Reza Shams-Ardekani

Abstract

Background: Ferulago carduchorum Boiss and Hausskn belongs to the Apiaceae family. This plant grows in west part of Iran that local people added it to dairy and oil ghee to delay expiration date and give them a pleasant taste. The aim of this study was to investigate the antioxidant, antimicrobial, acetyl cholinesterase inhibition, cytotoxic, larvicidal activities and composition of essential oil of F. carduchorum.
Methods: Acetyl cholinesterase (AChE) inhibitory, larvicidal activities and chemical composition of essential oil of F. carduchorum were investigated. Besides, antioxidant, antimicrobial and cytotoxic activities of essential oil were tested using DPPH, microdilution method and MTT assay, respectively.
Results: The major components of essential oil were (z)-β-ocimene (43.3%), α-pinene (18.23%) and bornyl acetate (3.98%). Among 43 identified components, monoterpenes were the most compounds (84.63%). The essential oil had noticeable efficiency against Candida albicans (MIC= 2340 μg ml-1) and it was effective against Anopheles
stephensi with LC50 and LC90 values of 12.78 and 47.43 ppm, respectively. The essential oil could inhibit AChE (IC50= 23.6 μl ml-1). The essential oil showed high cytotoxicity on T47D, HEP-G2 and HT-29 cell lines (IC50< 2 μg ml-1).
Conclusion: The essential oil of F. carduchorum collected from west of Iran had anti-Candida, larvicidal and cytotoxicity effects and should be further investigated in others in vitro and in vivo experimental models.

Aazza S, Lyoussi B, Miguel MG (2011) An- tioxidant and antiacetyl cholinesterase activities of some commercial essential oils and their major compounds. Mole- cules. 6: 7672–7690.

Abbott WS (1925) A method of computing the effectiveness of an insecticide. J Econ Entomol. 18: 265–267.

Adams RP (1995) Identification of Essential oil Components by Gas Chromatog- raphy/ Mass pectroscopy. Carol Stream, Illinois: Allured Publishing Corpora- tion. ISBN-10: 1932633219.

Andrianova VB, Sklyar YuE, Pimenov MG (1975) Coumarins of Ferulago turcomanica roots. Khim Prir Soedin. 11:514.

Baser KHC, Demirci B, Ozek T, Akalin E, Ozhatay N (2002) Micro Distilled Vol- atile Compounds from Ferulago Spe- cies Growing in Western Turkey. Pharm Boil. 40: 466–471.

Basile A, Sorbo S, Spadaro V, Bruno M, Maggio A, Faraone N, Rosselli S (2009) Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae). Molecules.14: 939–952.

Cecchini C, M. Coman M, Cresci A, Tirillini B, Cristalli G, Papa F, Sagratini G, Vittoric S, Maggid F (2010) Essential oil from fruits and roots of Ferulago campestris (Besser) Grecescu (Apiaceae): composition and antioxidant and anti- Candida activity. Flavour Frag. J. 25:493–502

Dall'Acqua S, Maggi F, Minesso P, Salvagno M, Papa F, Vittori S, Innocenti G (2010) Identification of nonalkaloid acetyl cho- linesterase inhibitors from Ferulago campestris (Besser) Grecescu (Apiaceae). Fitoterapia. 81: 1208–1212.

Demetzos C, Perdetzoglou D, Gazouli M, Tan K, Economakis C (2000) Chemical anal ysis and antimicrobial studies on three species of Ferulago from Greece. Planta Med. 66(6): 560–563.

De Pascual TJ, Jimenez B, Corrales B, Grande M (1979) Coumarins from Ferulago granatensis group:isovaleryl marmesin. An Quim. 75: 175–176.

Dharmagadda VSS, Naik SN, Mittal PK, Vasudevan P (2005) Larvicidal activity of Tagetes patula essential oil against three mosquito species. Biores Tech- no. 96: 1235–1240.

Doganca S, Tuzlaci E, Ulubelen A (1992) Constituents of Ferulago asperigifolia. Fitoterapia. 63 (6): 552.

Doganca S, Ulubelen A, Tuzlaci E (1991) 1- Acetylhydroquinone 4-galactoside from Ferulago aucheri. Phytochemistry. 30:2803–2805.

Erdurak CS, Coskun M, Demirci B, Baser KHC (2006) Composition of the essen- tial oil of fruits and roots of Ferulago isaurica Pesmen and F. syriaca Boiss. (Umbelliferae) from Turkey. Flavour Frag J. 21: 118–121.

Grutzendler J, Morris JC (2001) Cholines- terase inhibitors for alzheimer's dis- ease. Drugs. 61: 41–52.

Hadjiakhoondi A, Aghel N, Zamanizadeh N, Vatandoost H (2008a) Chemical and biological study of Mentha spicata L. essential oil from Iran. Daru. 8: 19–21.

Hadjiakhoondi A, Vatandoost H, Abousaber M, Khanavi M, Abdi L (2008b) Chemical composition of the essential oil of Tagetes minuta L. and its effects on Anopheles stephensi larvae in Iran. J Med Plant. 7(26): 33–100.

Hadjiakhoondi A, Sadeghipour-Roodsari HR, Vatandoost H, Khanavi M, Abaee MR, Vosoughi M (2006) Fatty acid composition and toxicity of Melia azedarach L. fruits against malaria vector Anopheles stephensi. Iranian J Pharm Sci. 2(2): 97–102.

Hadjiakhoondi A, Vatandoost H, Khanavi M,Abaee MR (2005) Biochemical in- vestigation of different extracts and larvicidal activity of Tagetes minuta L on Anopheles stephensi larvae. Iran J Pharm Sci .1: 81–84.

Hadjiakhoondi A, Vatandoost H, Jamshidi A, Bagherj Amiri E (2003) Chemical con- stituents and efficacy of Cymbopogon olivieri (Boiss) bar essential oil against malaria vector, Anopheles stephensi. Daru. 11(3): 125–128.

James AA (1992) Mosquito molecular ge- netics: the hands that feed bite back. Science. 257: 37–38.

Jimenez B, Grande MC, Anaya J, Torres P, Grande M (2000) Coumarins from Ferulago capillaris and F. brachyloba. Phytochemistry. 53: 1025–1031.

Karimi GH, Iranshahi M, Hosseinalizadeh F, Riahi B, Sahebkar A (2010) Screening of acetyl cholinesterase inhibitory ac- tivity of terpenoid and coumarin deriv- atives from the genus Ferula. Pharma- cologyonline. 1: 566–574.

Khalighi-Sigaroodi F, Hadjiakhoondi A, Shafiee A, Mozaffarian VA, Shahverdi AR, Alavi SHR (2006) Phytochemical analysis of Ferulogo Bernardii Tomk and M Pimen. Daru. 14: 214–221.

Khalighi-Sigaroodi F, Hadjiakhoondi A, Shahverdi AR, Mozaffarian V, Shafiee A (2005) Chemical composition and antimicrobial activity of the essential oil of Ferulago Bernardii Tomk and M Pimen. Daru. 13: 100–104.

Khanahmadi M, Janfeshan K (2006) Study on antioxidant property of Ferulago angulata plant. Asian J Plant Sci. 5:521–526.

Khanavi M, Vatandoost H, Khosravi Dehaghi N, Sanei Dehkordi A, Sedaghat MM, Hadjiakhoondi A, Hadjiakhoondi F (2013) Larvicidal Activities of Some Iranian Native Plants against the Main Malaria Vector, Anopheles stephensi. Acta Med Iran. 51: 141–147.

Khanavi M, Fallah A, Vatandoost H, Sedaghat M, Abai MR, Hadjiakhoondi A (2012a) Larvicidal activity of essen- tial oil and methanol extract of Nepeta menthoides against malaria vector Anoph- eles stephensi. Asian Pac J Trop Med.5(12): 962–965.

Khanavi M, Manayi A, Lotfi M, Abbasi R, Majdzadeh M, Ostad N (2012b) In- vestigation of Cytotoxic Activity in Four Stachys Species from Iran. Iran J Pharm Res. 11: 589–593.

Khanavi M, Rajabi A, Behzad M, Hadji- akhoondi A, Vatandoost H, Abaee MR (2011) Larvicidal Activity of Centaurea bruguierana ssp. belangerana Against Anopheles stephensi Larvae. Iran J Pharm Res. 10(4): 829–833.

Khanavi M, Pourmoslemi Sh, Farahanikia B, Hadjiakhoondi A, Ostad N (2010) Cytotoxicity of Vinca minor. Pharm Biol. 48(1): 96–100.

Khanavi M, Saghari Z, Mohammadirad A, Khademi R, Hadjiakhoondi A, Abdollahi M (2009) Comparison of antioxidant activity and total phenols of some date varieties. Daru. 17: 104–108.

Kilic CS, Ozkan AMG, Demirci B, Coskun M, Baser KHC (2010) Essential oil composition of four endemic Ferulago species growing in Turkey. Nat Prod Commun. 5: 1951–1954.

Maisonneune SA (1975) European Pharma- copoeia. Vol. 3. Saint-Ruffine. France.

Miyazawa M, Yamafuji C (2005) Inhibition of acetyl cholinesterase activity by bi- cyclic monoterpenoids. J Agric Food Chem. 53: 1765–1768.

Mozaffarian V (2007) A Dictionary of Ira- nian Plant Names. Farhange Moaser, Tehran.

NCCLS (2006) Methods for dilution antimi- crobial susceptibility tests for bacteria that grow aerobically. Approved Stand- ard M7-A7. PA, Wayne.

Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod .70: 461–477. Ognyanov I, Bocheva D (1969) Natural coumarins. II: Coumarins in Ferulago meoides. Planta Med. 17: 65–70.

Pinto E, Hrimpeng K, Lopes G, Vaz S, Gonçalves MJ, Cavaleiro C, Salgueiro L (2013) Antifungal activity of Ferulago capillaris essential oil against Can- dida, Cryptococcus, Aspergillus and dermatophyte species. Eur J Clin Microbiol Infect Dis. 32(10): 1311–1120.

Rahimifard N, Pakzad SR, Shoeibi Sh, Hedayati MH, Hajimehdipour H, MotahariniaV, Mehrafshan L, Javadi A, Pirali HamedaniV, Mehrafshan L, Javadi A, Pirali Hamedani M (2009) Effects of essential oil and extract of Thymus vulgaris, Zataria multiflora and Eugenia carryophilata on Vero, Hela, Hep2 cell lines by MTT assay. J Med Plants. 8: 152–156.

Rechinger KH (1978) Flora Iranica (Um- belliferae). Vol. 62. Graz: Akademische Druck-u. Verlagsanstalt. Germany.

Rosselli S, Maggio AM, Faraone N, Spadaro V, Morris-Natschke SL, Bastow KF, Lee KH, Bruno M (2009) The cyto- toxic properties of natural coumarins isolated from roots of Ferulago campestris (Apiaceae) and of synthetic ester derivatives of aegelino. Nat Prod Commun. 4(12): 1701–1706.

Ruberto G, Cannizzo S, Amico V, Bizzini M, Piattelli M (1994) Chemical con- stituents of Ferulago nodosa. J Nat Prod. 57: 1731–1733.

Samiee K, Akhgar MR, Rustaiyan A, Masoudi SH (2006) Composition of the vola- tiles of Ferulago carduchorum Boiss and Hausskn and Levisticum officinale Koch obtained by hydrodistillation and extraction. J Essent Oil Res. 18: 19–22.

Sedaghat MM, Sanei Dehkordi A, Abai MR, Khanavi M, Mohtarami F, Salim Abadi Y, Rafi F, Vatandoost H (2011) Lar- vicidal activity of essential oils of Apiaceae plants against malaria vector, Anopheles stephensi. Iran J Arthropod Borne Dis. 5: 51–59.

Sedaghat MM, Sanei Dehkordi AR, Khnavi M, Abai MR, Hadjiakhoondi A, Mohtarami F, Vatandoost H (2010) Phytochemistry and larvicidal activity of Eucalyptus camaldulensis against malaria vector, Anopheles stephensi. Asian Pac J Trop Med. 10: 841–845.

Sedaghat MM, Harbach RE (2005) An an- notated checklist of the Anopheles mos- quitoes (Diptera: Culicidae) in Iran. J Vect Ecol. 30: 272–276.

Serkerov SV, Kagramanov AA, Abbasov RM (1976) Coumarins of Ferulago turcomanica. Khim Prir Soedin. 1: 94.

Shen Q, Peng Q, Shao J, Liu X, Huang Z, Pu X, Ma L, Li YM, Chan AS, Gu L (2005) Synthesis and biological evalu- ation of functionalized coumarins as acetyl cholinesterase inhibitors. Eur J Med Chem. 40: 1307–1315.

Sklyar YE, Andrianova VB, Pimenov MG (1982) Coumarins of the roots of Ferulago sylvatica. Chem Nat Comp. 18:488–489.

Sodeifian GH, Ansari K, Bamoniri A (2011) Study of chemical composition of the essential oil of Ferulago angulata (schelcht) Boiss from Iran using super critical fluid extraction and nano scale injection. J Nanomaterials and Bio- structures. 161–168.

Vatandoost H, Emami SN, Oshaghi MA, Abai MR, Raeisi A, Piazzak N, Mahmoodi M, Akbarzadeh K, Sartipi M (2011) Ecology of malaria vector Anopheles culicifacies in a malarious area of Sistan va Baluchestan Province, southeast Is- lamic Republic of Iran. East Mediterr Health J. 17: 439–445.

Vatandoost H, Khazani A, KebriainZadeh A, Rafinejad J, Vatandoost H, Khazani A, KebriainZadeh A, Rafinejad J, Khoobdel M, Abai MR (2008) Comparative effi- cacy of Neem and dimethyl phthalate (DMP) against malaria vector, Anoph- eles stephensi (Diptera: Culicidae). Asian Pacific J Trop Med. 1(3): 1–6.

Weinstock M (1997) Possible role of the cholinergic system and disease mod- els. J Neural Transm. 49: 93–102.

Yokozawa T, Chen CP, Dong E, Tanka- Nonaka I (1998) Study on the inhibi- tory effect on tannins and flavonoids against the DPPH radical. Biochem Pharmacol. 50: 213–222.

Zhou X, Wang XB, Wang T, Kong LY (2008) Design, synthesis, and acetyl cholinesterase inhibitory activity of novel coumarin analogues. Bioorgan Med Chem. 16: 8011–8021

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Issue	Vol 9 No 1 (2015)
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Keywords
Ferulago carduchorum Essential oil Antimicrobial Antiacetyl cholinesterase Larvicidal activity

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Golfakhrabadi F, Khanavi M, Ostad SN, Saeidnia S, Vatandoost H, Abai MR, Hafizi M, Yousefbeyk F, Razzaghi Rad Y, Baghenegadian A, Shams-Ardekani MR. Biological Activities and Composition of Ferulago carduchorum Essential Oil. J Arthropod Borne Dis. 2015;9(1):104-115.

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