Crimean-Congo Hemorrhagic Fever in the One-Humped Camel (Camelus dromedarius) in East and Northeast of Iran
-
Mohsen Champour
,
Sadegh Chinikar
,
Gholamreza Mohammadi
,
Gholamreza Razmi
,
Ehsan Mostafavi
,
Nariman Shah-Hosseini
,
Sahar Khakifirouz
,
Tahmineh Jalali
Abstract
Background: This comprehensive study was conducted on multi-purpose one-humped camel (Camelus dromedarius) sera and ticks to assess the epidemiological aspects of the Crimean-Congo hemorrhagic fever virus (CCHFV) in northeast Iran.
Methods: From May 2012 to January 2013, eleven cities were randomly selected in the Khorasan Provinces of Iran as “clusters,” and at least 14 one-humped camels were sampled from each area. Reverse transcriptase polymerase chain reaction was used for the detection of the CCHFV genome in ticks. Sera were analyzed using specific enzyme-linked immunosorbent assay tests.
Results: Four hundred and eighty ixodid ticks were collected, and the genome of the CCHFV was detected in 49 (10.2%) out of 480 ticks. The CCHFV genome was detected in two out of four tick species, and in tick samples from three cities in Khorassan-e-Jonoobi. All three provinces, and six out of eleven cities, were CCHFV-specific IgG-positive. In total, nine (5.3%) out of 170 one-humped camels were IgG-positive. The highest rate of IgG-positive samples was found in Nehbandan (16.67%).
Conclusion: Continued surveillance and strictly enforced importation and quarantine practices should be implemented to prevent human exposure and the on-going dispersal of infected ticks and livestock in these regions. It is recommended that acaricides be used to prevent CCHF transmission to humans, and to reduce the tick population. In addition, care should be taken by abattoirs workers and people who work with one-humped camels.
Alavi-Naini R, Moghtaderi A, Koohpayeh HR, Sharifi-Mood B, Naderi M, Metanat M, Izadi M (2006) Crimean-Congo hem- orrhagic fever in southeast of Iran. J Infect. 52: 378–382.
Apanaskevich DA, Filippova NA (2007) Larval identification of species and subspecies of the genus Hyalomma (Acari: Ixodidae) from Russia and neighboring territories. parazitologiia. (41): 268–283.
Champour M, Mohammadi GR, Chinikar S, Razmi GR, Mostafavi E, Jalali T (2013) Frequency of hard-ticks and the influence of age and sex of camel on ticks' infestation rates in one-humped camel (Camelus dromedarius) popula- tion in the northeast of Iran. Sci Parasitol. 14(2): 89–93.
Chinikar S, Persson SM, Johansson M, Bladh L, Goya M, Houshmand B, Mirazimi A, Plyusnin A, Lundkvist A, Nilsson M (2004) Genetic analysis of Crimean- Congo hemorrhagic fever virus in Iran. J Med Virol. 73(3): 404–411.
Chinikar S, Mazaheri V, Mirahmadi R, Nabeth P, Francoise Saron M, Salehi P, Hosseini N, Bouloy M, Mirazimi A, Lundkvist A, Nilsson M, Mehrabi- Tavana A (2005) A serological survey in suspected human patients of Cri- mean-Congo hemorrhagic fever in Iran by determination of IgM specific ELISA method during 2000–2004. Arch Iran Med. (8): 52–55.
Chinikar S, Goya MM, Shirzadi MR, Ghiasi SA, Mirahmadi R, Haeri A, Moradi M, Afzali N, Rahpeyma M, Zeinali M, Meshkat M (2008) Surveillance and laboratory detection system of Crimean- Congo hemorrhagic fever in Iran. Trans- bound Emerg Dis. (55): 200–202.
Chinikar S, Ghiasi SM, Ghalyanchi- Langeroudi A, Goya MM, Shirzadi MR, Zeinali M, Haeri A (2009) An overview of Crimean-Congo Hemor- rhagic Fever in Iran. Iran J Microbiol.
(1): 7–12.
Chinikar S, Ghiasi SM, Hewson R, Moradi M, Haeri A (2010) Crimean-Congo hemorrhagic fever in Iran and neigh- boring countries. J Clin Virol. (47):110–114.
Chinikar S, Shah-Hosseini N, Bouzari S, Jalali T, Shokrgozar MA, Mostafavi E (2012) New circulating genomic vari- ant of Crimean-Congo hemorrhagic fever virus in Iran. Arch Virol. 158(5):1085–1088.
Duh D, Nichol ST, Khristova ML, Saksida A, Hafner Bratkovic I, Petrovec M, Dedushaj I, Ahmeti S, Avsic-zupanc T (2008) The complete genome sequence of a Crimean-Congo hemorrhagic fe- ver virus isolated from an endemic re- gion in Kosovo. Virol J. 14: 5–7.
Ergonul O (2006) Crimean-Congo hemor- rhagic fever. Lancet Infect Dis. 6(4):203–214.
Food and Agriculture Organization of the United Nations (2011) Available at: http://faostat.fao.org.
Garcia S, Chinikar S, Coudrier D, Billecocq A, Hooshmand B, Crance GM, Garin D, Bouloy M (2006) Evaluation of a Crimean- Congo hemorrhagic fever vi- rus recombinant antigen expressed by Semliki Forest Suicide virus for IgM and IgG antibody detection in human and animal sera collected in Iran. J Clin Virol. (35):154–159.
Hoogstraal H (1979) The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. J Med Entomol. 15: 307–317.
Izadi S, Holakouie-Naieni K, Majdzadeh SR, Chinikar S, Nadim A (2006) Seroprevalence of Crimean-Congo hem- orrhagic fever in Sistan-va-Baluchestan Province of Iran. Jpn J Infect Dis. 59:326–328.
Lawal MD, Amen IG, Ahmed A (2007) Some ectoparasites of Camelus dromedarius in Soko Nigeria. J Entomol. :143–148.
Minstry of Jihad-e- Agriculture (2002) Jihad- e- Agriculture in the mirror of statis- tics. no, Deputy for Livestock Affairs, Minstry of Jihad-e- Agriculture. Teh- ran, Iran. Available at: http:// www. maj.ir.
Moradi AR, Chinikar S, Oshaghi MA, Vatandoost H, Naeini Kh, Zahirnia AH, Telmadarraiy Z (2008) Molecular detection of Crimean-Congo hemor- rhagic fever (CCHF) virus in Ticks (Ixodidae, Argasidae) of Hamadan Province, Iran. Biochem Cell. 8(1):119–123.
Nabian S, Rahbari S (2008) Occurrence of soft and hard ticks on ruminants in Zagros mountainous areas of Iran. Iran J Arthropod-Borne Dis. 2: 16–20.
Papa A, Velo E, Papadimitriou E, Cahani G, Kota M, Bino S (2009) Ecology of the Crimean-Congo hemorrhagic fever endemic area in Albania. Vector Borne Zoonotic Dis. 9(6): 713–716.
Salim Abadi Y, Chinikar S, Telmadarriy Z, Vatandoost H, Moradi M, Oshaghi AM, Ghiasi SM (2011) Crimean– Congo hemorrhagic fever: a molecular survey on hard ticks (Ixodidae) in Yazd Province, Iran. Asian Pac J Trop Med. 4(1): 61–63.
Salimabadi Y, Telmadarriy Z, Vatandoost H, Chinikar S, Oshaghi MA, Moradi M, Mirabzadeh E, kmat S, Nasir A (2010) Hard ticks on domestic ruminants and their seasonal population dynamics in Yazd Province Iran. Iran J Arthropod- Borne Dis. 4: 66–71.
Saidi S, Casals J, Faghih MA (1975) Crimean hemorrhagic fever-Congo (CHF-C) virus antibodies in men, and in domes- tic and small mammals in Iran. Am J Trop Med Hyg. 24(2): 353–355.
Saijo M, Qing T, Niikura M, Maeda A, Ikegami T, Sakai K, Prehaud C, Kurane I, Morikawa S (2002) Immunofluo- rescence technique using HeLa cells expressing recombinant nucleoprotein for detection of immunoglobulin G antibodies to Crimean-Congo hemor- rhagic fever virus. J Clin Microbiol.40: 372–376.
Steele JH (1994) Handbook series in zoonoses section B, Viral Zoonoses. Vol 2, CRC Press, US.
Tahmasebi F, Ghiasi SM, Mostafavi E, Moradi M, Piazak N, Mozafari A, Haeri A, Chinikar S (2010) Molecular epi- demiology of Crimean-Congo hemor- rhagic fever virus genome isolated from ticks of Hamadan Province of Iran. J Vector Borne Dis. 47(4): 211–216.
Telmadarraiy Z, Ghiasi SM, Moradi M, Vatandoost H, Eshraghian MR, Faghihi F, Zarei Z, Haeri A, Chinikar S (2010)A survey of Crimean-Congo hemor- rhagic fever in livestock and ticks in Ardabil Province, Iran during 2004-2005. Scand J Infect Dis. 42(2): 137–141.
Williams RJ, Al-Busaidy S, Mehta FR, Maupin GO, Wagoner KD, Al-Awaidy S, Sulei- man AJ, Khan AS, Peters CJ, Ksiazek TG (2000) Crimean-Congo hemorrhagic fever: A seroepidemiological and tick survey in the Sultanate of Oman. Trop Med Int Health. 5(2): 99–106.
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| Issue | Vol 10 No 2 (2016) | |
| Section | Original Article | |
| Keywords | ||
| Epidemiology Survey CCHFV ELISA RT-PCR Iran | ||
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