Efficacy of Aloe Vera Cream in the Treatment of Paederus Dermatitis in Mice

  • Ramin Khaghani Mail Department of Medical Parasitology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran
  • Iraj Mirzaii-Dizgah Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran
  • Mostafa Ghasemi Department of Medical Parasitology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran
Paederus, Dermatitis, Aloe vera


Background: Dermatitis caused by Paederus beetle involves many people around the world, especially Iran. The symptoms include redness, itching and severe irritation. This study evaluated the effectiveness of the Aloe vera cream on the treatment of dermatitis caused by Paederus beetles.Methods: Forty male 6–8 weeks BALB/C mice were randomly divided into four groups of 10 mice. After removing the mice’s back hair, the backs of mice were marked by a circle with a diameter of 3 mm. The Paederus beetles were collected from Babol in Mazandaran Province, northern Iran and transferred to the animal lab of Aja University of Medical Sciences, Tehran, Iran. The end of abdominal segment Paederus was cut with scissors and hemolymph content was pushed by forceps on the circle. Only hemolymph of one Paederus applied to the back of each mouse. Groups 1, 2, 3 and 4 were treated with the base (vehicle), dexamethasone 0.1%, Aloe vera 0.5% and Aloe vera 2% creams respectively. After 2 days, dermatitis appeared. Then the mentioned creams were applied on the mice once a day. The wound area was measured every day. Dermatitis surface area under curve (AUC) of each mouse was cal­culated for 17 days after induction of dermatitis. Statistical analysis of ANOVA was used.Results: Application of Aloe vera 0.5% and 2% significantly reduced the healing duration and dermatitis area in comparison with the vehicle and dexamethasone cream (P< 0.05). But dexamethasone had no significant effect on the healing of dermatitis as compared to vehicle.Conclusion: Aloe vera may clinically effective in the treatment of Paederus dermatitis.


Agarry OO, Olaleye MT, Bello-Michael CO (2005) Comparative antimicrobial ac- tivities of Aloe vera gel and leaf. Afr J Biotechnol. 4(12): 1413–1414.

Babaee N, Zabihi E, Mohseni S, Moghadam- nia AA (2012) Evaluation of the ther- apeutic effects of Aloe vera gel on mi- nor recurrent aphthous stomatitis. Dent Res J (Isfahan). 9(4): 381–385.

Brega A, Falaschi A, Carli L De, Mario P (1968) Studies on the mechanism of action of pederine. J Cell Biol. 36(3):485–496.

Coiffait H (1982) Coleopteres Staphylinidae de la region Palearctique Occidentale. Sous famille Paederinae, Tribu Paederini (Paederi, Lathrobii). Nouv Rev Ento- mol. 7: 1–440.

Dagne E, Bisrat D, Viljoen A, Van Wyk BE (2000) Chemistry of Aloe species. Curr Org Chem. 4(10): 1055–1078.

Eshun K, He Q (2004) Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries-a review. Crit Rev Food Sci Nutr. 44(2): 91–96.

Frank J H and Kanamitsu K (1987) Paede- rus. sensu lato (Coleoptera: Staphylin- idae): natural history and medical im- portance. J Med Entomol. 24(2): 155–191.

Qadir SN, Raza N, Rahman SB (2006) Pae- derus dermatitis in Sierra Leone. Der- matol Online J. 12(7): 9.

Gelmetti C, Grimalt R (1993) Paederus der- matitis: An easy diagnosable but mis diagnosed eruption. Eur J Pediatr. 152 (1): 6–8.

George AO, Hart PD (1990) Outbreak of Paederus Dermatitis in Southern Nige- ria. Int J Dermatol. 29(7): 500–501.

Habeeb F, Shakir E, Bradbury F, Cameron P, Taravati MR, Drummond AJ, Gray AI, Ferro VA (2007) Screening meth- ods used to determine the anti-micro- bial properties of Aloe vera inner gel. Methods. 42(4): 315–320.

Hamman JH (2008) Composition and appli- cations of Aloe vera leaf gel. Mole- cules. 13(8): 1599–1616.

Hu Q, Hu Y, Xu J (2005) Free radical-scav- enging activity of Aloe vera (Aloe bar- badensis Miller) extracts by supercriti- cal carbon dioxide extraction. Food Chem. 91(1): 85–90.

Deneys JB, Zumpt F (1963) Rove beetel dermatitis in south West Africa. S Afr Med J. 37: 1284–1285.

Kerdel-Vegas F, Goihman-Yahr M (1966) Paederus dermatitis. Arch Dermatol. 94(2): 175–185.

Maenthaisong R, Chaiyakunapruk N, Ni- runtraporn S, Kongkaew C (2007) The efficacy of Aloe vera used for burn wound healing: A systematic review. Burns. 33(6): 713–718.

Mansour G, Ouda S, Shaker A, Abdallah HM (2014) Clinical efficacy of new Aloe vera- and myrrh-based oral mu- coadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-con- trolled study. J Oral Pathol Med. 43(6):405–409.

Molazem Z, Mohseni F, Younesi M, Keshavar- zi S (2014) Aloe vera gel and cesarean wound healing, a randomized controlled clinical trial. Glob J Health Sci. 7(1):203–209.

Nikbakhtzadeh M, Tirgari S (2008) Medi- cally important beetles (insecta: cole- optera) of Iran. J Venom Anim Toxins.14(4): 597–618.

Piel J (2002) A polyketide synthase-peptide synthetase gene cluster from an un- cultured bacterial symbiont of Paede- rus beetles. Proc Natl Acad Sci USA.99(22): 14002–14007.

Reynolds T, Dweck AC (1999) Aloe vera leaf gel: a review update. J Ethnophar- macol. 68(1–3): 3–37.

Rodriguez-Bigas M, Cruz NI, Suarez A (1988) Comparative evaluation of Aloe vera in the management of burn wounds in guinea pigs. Plast Reconstr Surg. 81 (3): 386–389.

Rosca-Casian O, Parvu M, Vlase L, Tamas M (2007) Antifungal activity of Aloe vera leaves. Fitoterapia. 78(3): 219–222.

Salazar-Sánchez N, López-Jornet P, Camacho- Alonso F, Sánchez-Siles M (2010) Ef- ficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study. Oral Pathol Med.39(10): 735–740.

Tai-Nin Chow J, Williamson DA, Yates KM, Goux WJ (2005) Chemical character- ization of the immunomodulating pol- ysaccharide of Aloe vera L. Carbohydr Res. 340(6): 1131–1142.

Talmadge J, Chavez J, Jacobs L, Munger C, Chinnah T, Chow JT, Williamson D, Yates K (2004) Fractionation of Aloe vera L. inner gel, purification and mo- lecular profiling of activity. Int Im- munopharmacol. 4(14): 1757–1773.

Tang T, Yin L, Yang J, Shan G (2007) Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur J Pharmacol. 567(3): 177–185.

Tarameshloo M, Norouzian M, Zarein-Dolab S, Dadpay M, Mohsenifar J, Gazor R (2012) Aloe vera gel and thyroid hor- mone cream may improve wound heal- ing in Wistar rats. Anat Cell Biol. 45 (3): 170–177.

Vázquez B, Avila G, Segura D, Escalante B(1996) Antiinflammatory activity of ex- tracts from Aloe vera gel. J Ethnophar- macol. 55(1): 69–75.

Vogler BK, Ernst E (1999) Aloe vera: a sys- tematic review of its clinical effective- ness. Br J Gen Pract. 49(447): 823–828.

Werawatganon D, Rakananurak N, Sallapant S, Prueksapanich P, Somanawat K, Klaikeaw N, Rerknimitr R (2014) Aloe vera attenuated gastric injury on in- domethacin-induced gastropathy in rats. World J Gastroenterol. 20(48): 18330–18337.

West DP, Zhu YF (2003) Evaluation of Aloevera gel gloves in the treatment of dry skin associated with occupational ex- posure. Am J Infect Control. 31(1):40–42.

Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI (2002) Antioxidant free radical scavenging and anti-inflammatory effects of al- oesin derivatives in Aloe vera. Planta Med. 68(11): 957–960.

Zargari O, Kimyai-Asadi A, Fathalikhani F, Panahi M (2003) Paederus dermatitis in northern Iran: a report of 156 cases. Int J Dermatol. 42(8): 608–612.

How to Cite
Khaghani R, Mirzaii-Dizgah I, Ghasemi M. Efficacy of Aloe Vera Cream in the Treatment of Paederus Dermatitis in Mice. J Arthropod Borne Dis. 11(2):204-210.
Original Article