Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever

  • Murat Sefikogullari Pediatric Clinic, Private Samandağ Medical Center, Hatay, Turkey
  • Ali Kaya Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
  • Huseyin Aydin Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
  • Enver Sancakdar Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
  • Veysel Kenan Celik Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
  • Gokhan Bagci Mail Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
Crimean congo hemorrhagic fever, VEGF, HIF-1α, Sepsis, Children


Background: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease characterized by serious course, including acute viral fever, ecchymosis, thrombocytopenia, liver dysfunction and high rate of mortality. Hypoxia Inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor-A (VEGF-A) play an important role both in the inflamma­tory process and plasma leakage. The aim of this study was to define HIF-1α and VEGF-A serum levels obtained from CCHF patients and control group and to investigate whether these factors were correlated with the pathogenesis of this disease.Methods: Thirty cases younger than 17 yr confirmed by RT-PCR and/or ELISA for CCHF were included in this study. Thirty age and sex matched healthy peoples were enrolled as controls. Blood samples collected from the pa­tient and control groups. Serum levels of HIF-1α and VEGF-A were measured with ELISA.Results: Levels of HIF-1α and VEGF-A were statistically significantly increased in CCHF patients compared to the control group (P< 0.05).  A significant positive correlation was found between the levels of HIF-1α and VEGF-A in the patient group (P< 0.01). The levels of ALT, AST, CK, aPTT, WBC and Thrombocyte count were significantly higher in the patients than in the control group (P< 0.001). A positive correlation was found among the levels of AST and CK from biochemical parame­ters and VEGF and HIF-1α in the patient group (P< 0.05)Conclusion: HIF-1α and VEGF-A might play an important role in CCHF pathogenesis.


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How to Cite
Sefikogullari M, Kaya A, Aydin H, Sancakdar E, Celik VK, Bagci G. Increased Levels of VEGF-A and HIF-1α in Turkish Children with Crimean-Congo Hemorrhagic Fever. J Arthropod Borne Dis. 11(1):19-26.
Original Article